Neuropediatrics 2003; 34(6): 281-286
DOI: 10.1055/s-2003-44663
Original Article

Georg Thieme Verlag Stuttgart · New York

The Development of Cerebral Perfusion in Healthy Preterm and Term Neonates

M. Kehrer 1 , 2 , I. Krägeloh-Mann 1 , R. Goelz 2 , M. Schöning 1
  • 1Department of Child Neurology, University Children's Hospital, Tübingen, Germany
  • 2Department of Neonatology, University Children's Hospital, Tübingen, Germany
Further Information

Publication History

Received: March 27, 2003

Accepted after Revision: July 27, 2003

Publication Date:
18 December 2003 (online)

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Abstract

Quantitative measurement of cerebral blood flow (CBF) volume was performed by sonographic flowmetry of both internal carotid (ICA) and vertebral arteries (VA) in 113 healthy preterm and term infants of 32 - 42 weeks postmenstrual age (PA) in order to delineate the physiological characteristics of brain perfusion in a time period very sensitive to brain injury. Mean CBF volume increased with PA, beginning with 33 ± 9 ml/min in neonates of 32 - 34 weeks and rising to 45 ± 10, 58 ± 13, 69 ± 14, and 83 ± 16 ml/min, respectively, in the PA groups of 35 - 36, 37 - 38, 39 - 40 and 41 - 42 weeks. There was no difference in CBF volume between the sexes. The bilateral sum of flow volumes in both ICA and VA rose markedly with PA. The relative contribution of bilateral VA flow volume to total CBF volume was 26 ± 8 % and remained constant with PA. In addition, we calculated the approximate CBF (ml/100 g brain weight/min) using the brain weights of each child as estimated by means of an equation based on head circumference measurements. Estimated CBF correlated significantly with PA (r = 0.49; p ≤ 0.0001), reflecting the rising metabolic demand of the growing brain during the time period examined.

References

M. D. Martin Schöning

Department of Child Neurology
University Children's Hospital

Hoppe-Seyler-Straße 1

72076 Tübingen

Germany

Email: martin.schoening@med.uni-tuebingen.de